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(21) regarding the correlation between hyperinsulinemia and hyperandrogenism, to the foundational work by Dunaif and Nestler (19801990) that established the causal relationship between IR and PCOS (23, 24), and through to the debates on the universality of this axis following the formulation of the Rotterdam diagnostic criteria (2003) (25, 26)
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Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation
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